In the pharmaceutical industry, a great number of products are in the form of particulate solids. Since the mid-1980s, a new method of powder generation has appeared involving crystallisation with supercritical fluids (SCF). The rapid expansion of supercritical solutions (RESS) is a promising new process for the production of small and uniform particles.Several variables can influence the RESS process: the nozzle temperature, preexpansion pressure, the nozzle diameter, and geometry. In this work, a two-dimensional Lagrange interpolation method has been proposed to describe the size of nanoparticle forming through the rapid expansion of supercritical solutions, as a function of preexpansion pressure and nozzle temperature.